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It's a family saga. Rather than following the family member linearily, the author chose to focus on each character in a chapter, much like he did in The Corrections. It's very well-written, I really felt for the characters, and even the most debasing, disgusting and reprehensible behaviours seem acceptable within the context of this world.
The one issue I had with this book is that there is so much information on each character. I got bored for about a hundred pages that delved into American politics, and then another fifty or so pages that dealt with saving a bird species. I think that the author felt too passionately about these subjects to leave them out, and while they were a part of the characters, I didn't really see how they added any real value to the story.
This is a long book - over 700 pages - and definitely not a beach-read. If you enjoy dissections of humanity and family, and have long commutes to work, then this would be a good addition to your electronic reading device.